Effects of the administration of brewed Robusta coffee leaves on total antioxidant status in rats with high-fat, high-fructose diet-induced metabolic syndrome

Authors

  • Nurmasari Widyastuti Universitas Diponegoro, Faculty of Medicine, Department of Nutrition Science, Jl. Prof H. Soedarto, SH, Tembalang, 50275, Semarang, Indonesia, Tel.: +6281575897167, https://orcid.org/0000-0003-2964-2632
  • Gemala Anjani Universitas Diponegoro, Faculty of Medicine, Department of Nutrition Science, Jl. Prof H. Soedarto, SH, Tembalang, 50275, Semarang, Indonesia, Tel.: +6281285376785 https://orcid.org/0000-0002-7774-7693
  • Vita Gustin Almira Universitas Diponegoro, Faculty of Medicine, Department of Nutrition Science, Jl. Prof H. Soedarto, SH, Tembalang, 50275, Semarang, Indonesia, Tel.: +62896702780780 https://orcid.org/0000-0003-0432-9084
  • Suci Eka Putri Universitas Diponegoro, Faculty of Medicine, Department of Nutrition Science, Jl. Prof H. Soedarto, SH, Tembalang, 50275, Semarang, Indonesia, Tel.: +6282391182648
  • Amali Rica Pratiwi Universitas Diponegoro, Faculty of Medicine, Department of Nutrition Science, Jl. Prof H. Soedarto, SH, Tembalang, 50275, Semarang, Indonesia, Tel.: +6281232256199 https://orcid.org/0000-0003-1293-2174

DOI:

https://doi.org/10.5219/1350

Keywords:

metabolic syndrome, Robusta coffee leaves, total antioxidant

Abstract

Robusta coffee (Coffea canephora) leaves contain phytochemical compounds and have antioxidant and anti-diabetic effects. This study investigated the effect of brewed Robusta coffee leaves on the total antioxidant status in metabolic syndrome rats. Metabolic syndrome in rats was induced by high-fat-fructose diet containing pork oil (20%), cholesterol (1.5%), cholic acid (0.5%), standard feed (80%), and fructose (1 mL per 200 g BW). The animals were categorized into normal control group (K1), metabolic syndrome control group without treatment (K2), mangiferin treatment group (X1), brewed Robusta coffee leaves 0.09 g per 200 BW group (X2), brewed Robusta coffee leaves 0.18 g per 200 BW group (X3), and brewed Robusta coffee leaves 0.36 g per 200 BW group (X4). Each dose of the coffee leaves was brewed with 3.6 mL of water at 70 °C for 10 min. The intervention was administered for 28 days. There was a significant increase in the total antioxidant status (p <0.000) in all the groups. In conclusion, the administration of brewed Robusta coffee leaves increased the total antioxidant status in metabolic syndrome rats.

Downloads

Download data is not yet available.

References

Alipour, B., Rashidkhani, B., Edalati, S. 2016. Dietary flavonoid intake, total antioxidant capacity and lipid oxidative damage: A cross-sectional study of Iranian women. Nutrition, vol. 32, no. 5, p. 566-572. https://doi.org/10.1016/j.nut.2015.11.011

Arozal, W., Suyatna, F. D., Juniantito, V., Rosdiana, D. S., Amurugam, S., Aulia, R., Monayo, E. R., Siswandi, R. 2015. The Effects of Mangiferin (Mangifera indica L) in Doxorubicin-induced Cardiotoxicity in Rats. Drug Research, vol. 65, no. 11, p. 574-580. https://doi.org/10.1055/s-0034-1394457

Coskun, O., Kanter, M., Korkmaz, A., Oter, S. 2005. Quercetin, a flavonoid antioxidant, prevents and protects streptozotocin-induced oxidative stress and ß-cell damage in rat pancreas. Pharmacological Research, vol. 51, no. 2, p. 117-123. https://doi.org/10.1016/j.phrs.2004.06.002

Curtis, P. J., Sampson, M., Potter, J., Dhatariya, K., Kroon, P. A., Cassidy, A. 2012. Chronic Ingestion of Flavan-3-ols and Isoflavones Improves Insulin Sensitivity and Lipoprotein Status and Attenuates Estimated 10-Year CVD Risk in Medicated Postmenopausal Women With Type 2 Diabetes: A 1-year, double-blind, randomized, controlled trial. Diabetes Care, vol. 35, no. 2, p. 226-232. https://doi.org/10.2337/dc11-1443

de Souza Cardoso, J., Oliveira, P. S., Bona, N. P., Vasconcellos, F. A., Baldissarelli, J., Vizzotto, M., Pereira Soares, M. S., Ramos, V. P., Spanevello, R. M., Lencina, C. L., Tavares, R. G., Stefanello, F. M. 2018. Antioxidant, antihyperglycemic, and antidyslipidemic effects of Brazilian-native fruit extracts in an animal model of insulin resistance. Redox Report, vol. 23, no. 1, p. 41-46. https://doi.org/10.1080/13510002.2017.1375709

Demirtaş, C., Ofluoglu, E., Hussein, A., Pasaoglu, H. 2012. Effects of Caffeine on Oxidant-Antioxidant Mechanisms in the Rat Liver. Gazi Medical Journal, vol. 23, no. 1, p. 13-18. https://doi.org/10.5152/gmj.2012.04

Du, Z., Yang, Y., Hu, Y., Sun, Y., Zhang, S., Peng, W., Zhong, Y., Huang, X., Kong, W. 2012. A long-term high-fat diet increases oxidative stress, mitochondrial damage and apoptosis in the inner ear of d-galactose-induced aging rats. Hearing Research, vol. 287, no. 1-2, p. 15-24. https://doi.org/10.1016/j.heares.2012.04.012

Herningtyas, E. H., Ng, T. S. 2019. Prevalence and distribution of metabolic syndrome and its components among provinces and ethnic groups in Indonesia. BMC Public Health, vol. 19, 12 p. https://doi.org/10.1186/s12889-019-6711-7

Huang, B.-W., Chiang, M.-T., Yao, H.-T., Chiang, W. 2004. The effect of high-fat and high-fructose diets on glucose tolerance and plasma lipid and leptin levels in rats. Diabetes, Obesity and Metabolism, vol. 6, no. 2, p. 120-126. https://doi.org/10.1111/j.1462-8902.2004.00323.x

Hurrle, S., Hsu, W. H. 2017. The etiology of oxidative stress in insulin resistance. Biomedical Journal, vol. 40, no. 5, p. 257-262. https://doi.org/10.1016/j.bj.2017.06.007

Chen, X. 2019. A review on coffee leaves: Phytochemicals, bioactivities and applications. Critical Reviews in Food Science and Nutrition, vol. 59, no. 6, p. 1008-1025. https://doi.org/10.1080/10408398.2018.1546667

Chen, X.-M., Ma, Z., Kitts, D. D. 2018. Effects of processing method and age of leaves on phytochemical profiles and bioactivity of coffee leaves. Food Chemistry, vol. 249, p. 143-153. https://doi.org/10.1016/j.foodchem.2017.12.073

Imran, M., Arshad, M. S., Butt, M. S., Kwon, J.-H., Arshad, M. U., Sultan, M. T. 2017. Mangiferin: a natural miracle bioactive compound against lifestyle related disorders. Lipids in Health and Disease, vol. 16, 17 p. https://doi.org/10.1186/s12944-017-0449-y

Jeszka-Skowron, M., Sentkowska, A., Pyrzyńska, K., De Peña, M. P. 2016. Chlorogenic acids, caffeine content and antioxidant properties of green coffee extracts: influence of green coffee bean preparation. European Food Research and Technology, vol. 242, p. 1403-1409. https://doi.org/10.1007/s00217-016-2643-y

Kristiningrum, N., Cahyanti, Y. N., Wulandari, L. 2017. Determination of Total Phenolic Content And Antioxidant Activity In Methanolic Extract of Robusta and Arabica Coffee Leaves. UNEJ E-Proceeding, p. 96-99. Available at: https://jurnal.unej.ac.id/index.php/prosiding/article/view/3901

Lee, S. E., Han, K., Kang, Y. M., Kim, S.-O., Cho, Y. K., Ko, K. S., Park, J-Y., Lee, K-U., Koh, E. H. 2018. Trends in the prevalence of metabolic syndrome and its components in South Korea: Findings from the Korean National Health Insurance Service Database (2009–2013). PLOS ONE, vol. 13, no. 3, e0194490. https://doi.org/10.1371/journal.pone.0194490

Liang, N., Kitts, D. D. 2014. Antioxidant Property of Coffee Components: Assessment of Methods that Define Mechanisms of Action. Molecules, vol. 19, no. 11, p. 19180-19208. https://doi.org/10.3390/molecules191119180

Liang, N., Kitts, D. D. 2016. Role of Chlorogenic Acids in Controlling Oxidative and Inflammatory Stress Conditions. Nutrients, vol. 8, no. 1, 20 p. https://doi.org/10.3390/nu8010016

Mancini, A., Martorana, G. E., Magini, M., Festa, R., Raimondo, S., Silvestrini, A., Nicolotti, N., Mordente, A., Mele, M. C., Donato Miggiano, G. A., Meucci, E. 2015. Oxidative stress and metabolic syndrome: Effects of a natural antioxidants enriched diet on insulin resistance. Clinical Nutrition ESPEN, vol. 10, no. 2, p. e52-e60. https://doi.org/10.1016/j.clnesp.2014.11.002

Marseglia, L., Manti, S., D’Angelo, G., Nicotera, A., Parisi, E., Di Rosa, G., Gitto, E., Arrigo, T. 2015. Oxidative Stress in Obesity: A Critical Component in Human Diseases. International Journal of Molecular Sciences, vol. 16, no. 1, p. 378-400. https://doi.org/10.3390/ijms16010378

Metro, D., Cernaro, V., Santoro, D., Papa, M., Buemi, M., Benvenga, S., Manasseri, L. 2017. Beneficial effects of oral pure caffeine on oxidative stress. Journal of Clinical & Translational Endocrinology, vol. 10, p. 22-27. https://doi.org/10.1016/j.jcte.2017.10.001

Mirończuk-Chodakowska, I., Witkowska, A. M., Zujko, M. E. 2018. Endogenous non-enzymatic antioxidants in the human body. Advances in Medical Sciences, vol. 63, no. 1, p. 68-78. https://doi.org/10.1016/j.advms.2017.05.005

Morillas-Ruiz, J. M., Hernández-Sánchez, P. 2015. Oxidative Stress and Antioxidant Defenses Induced by Physical Exercise. In Gowder, S. J. T., Basic Principles and Clinical Significance of Oxidative Stress. London, UK : IntechOpen. ISBN: 978-953-51-2200-5. https://doi.org/10.5772/61547

Muruganandan, S., Gupta, S., Kataria, M., Lal, J., Gupta, P. K. 2002. Mangiferin Protects Streptozotocin-induced Oxidative Damage to Cardiac and Renal Tissues in Rats. Toxicology, vol. 176, no. 3, p. 165-173. https://doi.org/10.1016/S0300-483X(02)00069-0

Nugroho, A. E., Andrie, M., Warditiani, N. K., Siswanto, E., Pramono, S., Lukitaningsih, E. 2012. Antidiabetic and antihiperlipidemic effect of Andrographis paniculata (Burm. f.) Nees and andrographolide in high-fructose-fat-fed rats. Indian Journal of Pharmacology, vol. 44, no. 3, p. 377-381. https://doi.org/10.4103/0253-7613.96343

Octavia, Z. F., Djamiatun, K., Suci, N. 2017. Pengaruh pemberian yogurt sinbiotik tepung pisang tanduk terhadap profil lipid tikus sindrom metabolik (The effect of synbiotic yogurt of tanduk banana flour in lipid profi le of metabolic syndrome rats). Jurnal Gizi Klinik Indonesia, vol. 13, no. 4, p. 159-169. In Indonesian https://doi.org/10.22146/ijcn.19369

Pari, L., Karthikesan, K., Menon, V. P. 2010. Comparative and combined effect of chlorogenic acid and tetrahydrocurcumin on antioxidant disparities in chemical induced experimental diabetes. Molecular and Cellular Biochemistry, vol. 341, p. 109-117. https://doi.org/10.1007/s11010-010-0442-5

Rasyid, R., Sanjaya, W. F., Zulharmita. 2013. Penetapan Kadar Kofein Daun Kopi Kawa (Coffea Robusta, Lind) (The determenation of caffeine on leaves Kawa Coffee (Coffea Robusta, Lind)). Jurnal Farmasi Higea, vol. 5, no. 2, p. 137-143. In Indonesian

Sellamuthu, P. S., Arulselvan, P., Muniappan, B. P., Fakurazi, S., Kandasamy, M. 2013. Mangiferin from Salacia chinensis Prevents Oxidative Stress and Protects Pancreatic β -Cells in Streptozotocin-Induced Diabetic Rats. Journal of Medicinal Food, vol. 16, no. 8, p. 719-727. https://doi.org/10.1089/jmf.2012.2480

Sreekumar, R., Unnikrishnan, J., Fu, A., Nygren, J., Short, K. R., Schimke, J., Barazzoni, R., Sreekumaran Nair, K. 2002. Impact of high-fat diet and antioxidant supplement on mitochondrial functions and gene transcripts in rat muscle. American Journal of Physiology, Endocrinology and Metabolism, vol. 282, no. 5, p. E1055–E1061. https://doi.org/10.1152/ajpendo.00554.2001

Srikanthan, K., Feyh, A., Visweshwar, H., Shapiro, J. I., Sodhi, K. 2016. Systematic Review of Metabolic Syndrome Biomarkers: A Panel for Early Detection, Management, and Risk Stratification in the West Virginian Population. International Journal of Medical Sciences, vol. 13, no. 1, p. 25-38. https://doi.org/10.7150/ijms.13800

Tangvarasittichai, S. 2015. Oxidative stress, insulin resistance, dyslipidemia and type 2 diabetes mellitus. World Journal of Diabetes, vol. 6, no. 3, p. 456-480. https://doi.org/10.4239/wjd.v6.i3.456

Tellone, E., Galtieri, A., Giardina, B., Russo, A., Bellocco, E., Barreca, D., Ficarra, S. 2015. Antioxidant Activity of Caffeine: A Focus on Human Red Blood Cells nd Correlations with Several Neurodegenerative Disorders. In Preedy, V. R. Coffee in Health and Disease Prevention. London, UK : Academic Press, p. 835-842. https://doi.org/10.1016/B978-0-12-409517-5.00092-9

Wu, L. 2007. Effect of chlorogenic acid on antioxidant activity of Flos Lonicerae extracts. Journal of Zhejiang University SCIENCE B, vol. 8, p. 673-679. https://doi.org/10.1631/jzus.2007.B0673

Yadav, A., Kumari, R., Yadav, A., Mishra, J. P., Srivastava, S., Prabha, S. 2016. Antioxidants and its functions in human body - A Review. Research in Environment and Life Sciences, vol. 9, no. 11, p. 1328-1331.

Yamagata, K. 2018. Do Coffee Polyphenols Have a Preventive Action on Metabolic Syndrome Associated Endothelial Dysfunctions? An Assessment of the Current Evidence. Antioxidants, vol. 7, no. 2, 18 p. https://doi.org/10.3390/antiox7020026

Yamagata, K. 2019. Metabolic Syndrome: Preventive Effects of Dietary Flavonoids. In Studies in Natural Products Chemistry. Amsterdam, Netherland : Elsevier, vol. 60, p. 1-28. https://doi.org/10.1016/B978-0-444-64181-6.00001-2

Zhang, D.-M., Jiao, R.-Q., Kong, L.-D. 2017. High Dietary Fructose: Direct or Indirect Dangerous Factors Disturbing Tissue and Organ Functions. Nutrients, vol. 9, no. 4, 335 p. https://doi.org/10.3390/nu9040335

Published

2020-05-28

How to Cite

Widyastuti, N., Anjani, G., Almira, V. G., Putri, S. E., & Pratiwi, A. R. (2020). Effects of the administration of brewed Robusta coffee leaves on total antioxidant status in rats with high-fat, high-fructose diet-induced metabolic syndrome. Potravinarstvo Slovak Journal of Food Sciences, 14, 258–263. https://doi.org/10.5219/1350