Patin (Pangasius hypophthalmus) fish protein concentrate alters insulin-like growth factor (IGF)-1 and igf binding protein (IGFBP)-3 level of sprague dawley neonate rats-induced malnutrition


  • Annisa Zikra Abdullah Diponegoro University, Faculty of Medicine, Department of Nutrition, Tembalang, Semarang Indonesia 50275, Tel: +6282169779197
  • Samnil Astuti Fitri Diponegoro University, Faculty of Medicine, Department of Nutrition, Tembalang, Semarang Indonesia 50275, Tel: +6281266402421
  • Muflihatul Muniroh Diponegoro University, Faculty of Medicine, Department of Physiology, Tembalang, Semarang Indonesia 50275, Tel: +62(24)76928010/1
  • Tri Winarni Agustini Diponegoro University, Faculty of Fisheries and Marine Science, Department of Fishery Products Technology, Tembalang, Semarang Indonesia 50275, Tel: +6281390653646



FPC, Malnutrition, IGF-1, IGFBP-3


Malnutrition is caused by inadequate protein intake and affects growth factor. High protein from patin (Pangasius hypophthalmus) fish is a well-known protein source. This study aims to investigate the effect of patin fish protein concentrate (PFPC) in the IGF-1 and IGFBP-3 level of Sprague Dawley (SD) neonate rats-induced malnutrition. Thirty male SD neonate rats were divided randomly into five groups, namely normal control (K1), malnutrition control (K2), malnutrition with PFPC 13.26 mg.g-1 body weight (BW)/day (X1), malnutrition with PFPC 19.89 mg.g-1 BW/d (X2), and malnutrition with casein supplement 13.26 mg.g-1 BW/d (X3). K1 received a standard diet, while the others received a low 8% protein diet (L8PD) since those were born until 21 days. The standard diet was refed for all groups during the intervention (14 days). IGF-1 and IGFBP-3 levels were measured by ELISA. Normal data were analyzed by using One-way ANOVA which then was followed by post-hoc Bonferroni. Meanwhile, the others were analyzed by Kruskal Wallis and followed by Mann-Whitney U-test. Spearman test was used for correlation. PFPC contained 81.07% of protein, 4.08% of fat, 7.24% of moisture, 2.77% of ash, and 4.83% of carbohydrate. These contents had affected the growth factor. As a result, in the PFPC intervention, IGF-1, and IGFBP-3 levels (p <0.05) were decreased, while the controls were increased. The decreased values were shown in IGFBP-3 levels (p <0.05) while the increase was shown in both controls. On the other hand, the increase in body weight was shown in all groups, including control ones. A strong correlation was found between IGF-1 and IGFBP-3. PFPC has additional value on repairing malnutrition that is the best dose in effecting IGF-1 dan IGFBP3 levels is 13.26 mg.g-1 BW/d.


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How to Cite

Abdullah, A. Z., Fitri, S. A., Muniroh, M., & Agustini, T. W. (2020). Patin (Pangasius hypophthalmus) fish protein concentrate alters insulin-like growth factor (IGF)-1 and igf binding protein (IGFBP)-3 level of sprague dawley neonate rats-induced malnutrition . Potravinarstvo Slovak Journal of Food Sciences, 14, 1066–1074.