Satureja montana L. essential oil various dosages effect on the main rats’ biological features

Authors

  • Vladimir Pashtetsky Federal State Budget Scientific Institution “Research Institute of Agriculture of Crimea“ The Ministry of Science and Higher Education of the Russian Federation, Kievskaya-street, 150, 295493, Simferopol, Russia, Tel. +73652560007
  • Pavel Ostapchuk Field Crop Department, Federal State Budget Scientific Institution “Research Institute of Agriculture of Crimea“, The Ministry of Science and Higher Education of the Russian Federation, Kievskaya-street, 150, 295493, Simferopol, Russia, Tel. +73652560007
  • Elena Usmanova Field Crop Department, Federal State Budget Scientific Institution “Research Institute of Agriculture of Crimea“, The Ministry of Science and Higher Education of the Russian Federation, Kievskaya-street, 150, 295493, Simferopol, Russia, Tel. +73652560007
  • Eugenia Zyablitskaya Central Research Laboratory, Medical Academy named after S. I. Georgievsky (structural division) of the “V.I. Vernadsky Crimean Federal University“, The Ministry of Science and Higher Education of the Russian Federation, Lenin Boulevard, 5/7, 295051, Simferopol, Russia, Tel.: +73652601170
  • Tatiana Makalish Medical Academy named after S. I. Georgievsky (structural division) of the “V.I. Vernadsky Crimean Federal University“, The Ministry of Science and Higher Education of the Russian Federation, Lenin Boulevard, 5/7, 295051, Simferopol, Russia, Tel.: +73652601170
  • Irina Danilova Federal State Budget Scientific Institution “Research Institute of Agriculture of Crimea“, The Ministry of Science and Higher Education of the Russian Federation, Kievskaya-street, 150, 295493, Simferopol, Russia, Tel. +73652560007 https://orcid.org/0000-0001-9311-1479
  • Tatiana Kuevda Field Crop Department, Federal State Budget Scientific Institution “Research Institute of Agriculture of Crimea“, The Ministry of Science and Higher Education of the Russian Federation, Kievskaya-street, 150, 295493, Simferopol, Russia, Tel. +73652560007
  • Denis Zubochenko Laboratory of Molecular Genetics, Proteomics and Bioinformatics in Agriculture, Federal State Budget Scientific Institution “Research Institute of Agriculture of Crimea“, The Ministry of Science and Higher Education of the Russian Federation, Kievskaya-street, 150, 295493, Simferopol, Russia, Tel. +73652560007
  • Veronica Uppe Laboratory of Molecular Genetics, Proteomics and Bioinformatics in Agriculture, Federal State Budget Scientific Institution “Research Institute of Agriculture of Crimea“, The Ministry of Science and Higher Education of the Russian Federation, Kievskaya-street, 150, 295493, Simferopol, Russia, Tel. +73652560007 https://orcid.org/0000-0001-5978-045X
  • Aleksandra Pashtetskaia Field Crop Department, Federal State Budget Scientific Institution “Research Institute of Agriculture of Crimea“, The Ministry of Science and Higher Education of the Russian Federation, Kievskaya-street, 150, 295493, Simferopol, Russia, Tel. +73652560007
  • Anna Pikhtereva Processing and Standardization of Essential Oil Raw Materials Department, Federal State Budget Scientific Institution “Research Institute of Agriculture of Crimea“, The Ministry of Science and Higher Education of the Russian Federation, Kievskaya-street, 150, 295493, Simferopol, Russia, Tel. +73652560007
  • Viktor Abalduev Junior Researcher, Medical Academy named after S. I. Georgievsky (structural division) of the “V.I. Vernadsky Crimean Federal University“, The Ministry of Science and Higher Education of the Russian Federation, Lenin Boulevard, 5/7, 295051, Simferopol, Russia, Tel.: +73652601170
  • Vitalii Delov Medical Academy named after S. I. Georgievsky (structural division) of the “V.I. Vernadsky Crimean Federal University“, The Ministry of Science and Higher Education of the Russian Federation, Lenin Boulevard, 5/7, 295051, Simferopol, Russia, Tel.: +73652601170
  • Alina Posobilova Medical Academy named after S. I. Georgievsky (structural division) of the “V.I. Vernadsky Crimean Federal University“, The Ministry of Science and Higher Education of the Russian Federation, Lenin Boulevard, 5/7, 295051, Simferopol, Russia, Tel.: +73652601170 https://orcid.org/0000-0002-9554-5307

DOI:

https://doi.org/10.5219/1643

Keywords:

Satureja montana L., essential oil, rats, live weight, plasma, stomach, liver

Abstract

An application of natural antioxidants remains the focus of research groups. The effect of Satureja montana L. essential oil in various doses on the main biological characteristics of Wistar rats was the main aim of the study. The intensification of protein metabolism in the blood plasma of rats on the background of the use of Satureja montana L. essential oil was noted. Total protein increases by 17.9 – 19.7%, and albumin by 27.6% in rats of the experimental group received the essential oil at a dose of 0.6 ml per kg of feed. A significant increase in the AST level in control group rats to 207.3 U.L-1 was revealed. Its one to a certain extent indicates the hepatoprotective effect of mountain savory oil and a decrease in inflammatory processes in the organs of the gastrointestinal tract in the conditions of cell maintenance of rats of the experimental groups. Gastric epithelium thickness of rats of both experimental groups was lower than the control animals. But it did not bear any signs of atrophy. The difference of this indicator in comparison with control was 12.75 μm (p ≤0.05) in the second group and it was reliable. The number of chief stomach cells increases in animals of the experimental groups, which may indicate a greater enzymatic activity. An increased dose of mountain savory oil contributes to the formation of more damage to hepatocytes on the periphery of the liver lobule. Thus, the relationship between liver enzymes and the state of peripheral hepatocytes was noted.

Downloads

Download data is not yet available.

References

Allaoua, M., Etiene, P., Noirot, V., Carayon, J.-L., Téné, N., Bonnafé, E., Trelhou, M. 2018. Pharmacokinetic and antimicrobial activity of a new carvacrol-based product against a human pathogen, Campylobacter jejuni. Journal of Applied Microbiology, vol. 125, no. 4, p. 1162-1174. https://doi.org/10.1111/jam.13915.

Bae, D., Seol, H., Yoon, H.-O., Na, J.-R., Oh, K., Choi, Ch. Y., Le, D.-W., Jun, W., Lee, K. W., Lee, J., Hwang, K., Lee, Y.-H., Kim, S. 2012. Inhaled essential oil from Chamaecyparis obtuse ameliorates the impairments of cognitive function induced by injection of beta-amyloid in rats. Pharmaceutical Biology, vol. 50, no. 7, p. 900-910. https://doi.org/10.3109/13880209.2011.642886

Bagci, E., Aydin, E., Mihasan, M., Maniu, C., Hritcu, L. 2016. Anxiolytic and antidepressant-like effects of Ferulago angulata essential oil in the scopolamine rat model of Alzheimer's disease. Flavour And Fragrance Journal, vol. 31, no. 1, p. 70-80. https://doi.org/10.1002/ffj.3289

Campélo, L. M. L., Gonḉalves, F. C. M., Feitosa, Ch. M., de Freitas, R. M. 2011. Antioxidant activity of Citrus limon essential oil in mouse hippocampus. Pharmaceutical Biology, vol. 49, no. 7. p. 709-715. https://doi.org/10.3109/13880209.2010.541924.

Castro, M. R., Victoria, F. N., Oliveira, D. H., Jacob, R. G., Savegnango, L., Alves, D. 2015. Essential oil of Psidium cattleianum leaves: Antioxidant and antifungal activity. Pharmaceutical Biology, vol. 53, no. 2, p. 242-50. https://doi.org/10.3109/13880209.2014.914231

Chioca, L. R., Ferro, M. M., Baretta, I. P., Oliveira, S. M., Silva, C. R., Ferreira, J., Losso, E. M., Andreatini, R. 2013. Anxiolytic-like effect of lavender essential oil inhalation in mice: Participation of serotonergic but not GABA(A)/benzodiazepine neurotransmission. Journal of Ethnopharmacology, vol. 147, no. 2. p. 412-418. https://doi.org/10.1016/j.jep.2013.03.028

Choi, M.-S., Choi, B.-sub., Kim, S. H., Pak, S. Ch., Jang, Ch. H., Chin, Y.-W., Kim, Y.-M., Kim, D.-I., Jeon S., Koo, B.-S. 2015. Essential Oils from the Medicinal Herbs Upregulate Dopamine Transporter in Rat Pheochromocytoma Cells. Journal Of Medicinal Food, vol. 18, no. 10, p. 1112-20. https://doi.org/10.1089/jmf.2015.3475

Fabian, D., Juhás, Š., Bukovská, A., Bujňáková, D., Grešáková, Ľ., Koppel, J. 2011. Anti-inflammatory effects of chamomile essential oil in mice. Slovak Journal of Animal Science, vol. 44, no. 3, p. 111-116. Available at http://www.cvzv.sk/slju/11_3/Fabian-SJAS-3-2011.pdf.

Fauza, A., Al-Baarri, A. N., Djamiatun, K. 2019. Potency of Okra flour (Abelmoschus esculentus) in improving adiponectin level and total antioxidant capacity of high fat diet streptozotocin rat model. Potravinarstvo Slovak Journal of Food Sciences, vol. 13, no. 1, p. 644-650. https://doi.org/10.5219/1136

Krishan, G., Narang, A. 2014. Use of essential oils in poultry nutrition: A new approach. Journal of Advanced Veterinary and Animal Research, vol. 1, no. 4, p. 156-162. https://doi.org/10.5455/javar.2014.a36

Gradinariu, V., Cioanca, O., Hritcu, L., Trifan, A., Gille, E., Hancianu, M. 2015. Comparative efficacy of Ocimum sanctum L. and Ocimum basilicum L. essential oils against amyloid beta (1-42)-induced anxiety and depression in laboratory rats. Phytochemistry Reviews, vol. 14, no. 4, p. 567-575. https://doi.org/10.1007/s11101-014-9389-6

Hritcu, L., Cioanca, O., Hancianu, M. 2012. Effects of lavender oil inhalation on improving scopolamine-induced spatial memory impairment in laboratory rats. Phytomedicine, vol. 19, no. 6, p. 529-534. https://doi.org/10.1016/j.phymed.2012.02.002

Luo, B., Shi, H., Wang, L., Shi, Y., Wang, Ch., Yang, J., Wan, Y., Niu, J. 2014. Rat Lung Response to PM2.5 Exposure under Different Cold Stresses International Journal Environmental Research Public Health, vol. 11, p. 12915-12926. https://doi.org/10.3390/ijerph111212915

Mihajilov-Krstev, T., Jovanović, B., Jović, J., Ilić, B., Miladinović, D., Matejić, J., Rajković, J., Dorđević, L., Cvetković, V., Zlatković, B. 2014. Antimicrobial, antioxidative, and insect repellent effects of Artemisia absinthium essential oil. Planta Med, vol. 80, no. 18, p. 1698-705. https://doi.org/10.1055/s-0034-1383182

Monforte, M. T., Tzakou, O., Nostro, A., Zimbalatti, V., Galati, E. M. 2011. Composition and Biological Activities of Calamintha officinalis Moench Essential Oil. Journal of Medicinal Food, vol. 14, no. 3, p. 297-303. https://doi.org/10.1089/jmf.2009.0191

Nurmawati, L., Sulchan, M., Fatimah-Muis, S., Djagat Purnomo, H., Djamiatun, K., Ardiaria, M., Karlowee, V. 2021. The effect of single clove Black garlic on the hemostasis status and lipid profile in male Sprague Dawley rats with non-alcoholic fatty liver disease. Potravinarstvo Slovak Journal of Food Sciences, vol. 15, no. 1, p. 387-395. https://doi.org/10.5219/1516

Orchardand, A., van Vuuren, S. 2017. Commercial Essential Oils as Potential Antimicrobials to Treat Skin Diseases. Evidence-Based Complementary and Alternative Medicine, vol. 2017, p. 92. https://doi.org/10.1155/2017/4517971

Ostapchuk, P., Kuevda, T. A., Yemelyanov, S. A., Kashirina, A. N., Yermolaeva, V. M., Zyablitskaya, Yu. E., Makalish, P. T., Ostapova, S. V. 2020. Influence of Satureja Montana essential oil on biological indicators formation of broiler chickens. Proceedings of Nizhnevolzhskiy agrouniversity complex: science and higher vocational education, vol. 2, no. 58, p. 251-265. https://doi.org/10.32786/2071-9485-2020-02-25 (In Russian).

Oyemitan, I. A., Olayera, O. A., Alabi, A., Abass, L. A., Elusiyan, C. A., Oyedeji, A. O., Akanmu, M. A. 2015. Psychoneuropharmacological activities and chemical composition of essential oil of fresh fruits of Piper guineense (Piperaceae) in mice. Journal Of Ethnopharmacology vol. 166, p. 240-249. https://doi.org/10.1016/j.jep.2015.03.004

Park, H.-J., Lim, E-J., Zhao, R. J., Oh, S. R., Jung, J. W., Ahn, E-M., Lee, E. S., Koo, J. S., Kim, H. Y., Chang, S., Shim, H. S., Kim, K. J., Gwak, Y. S., Yang. Ch. H. 2015. Effect of the fragrance inhalation of essential oil from Asarum heterotropoides on depression-like behaviors in mice. BMC complementary and alternative medicine, vol. 15, no. 1, p. 571-578. https://doi.org/10.1186/s12906-015-0571-1

Pashtetsky, V., Ostapchuk, P., Postnikova, O., Zubochenko, D., Kuevda, T. 2020. Effect of Satureja montana essential oil on the bactericidal activity of broiler chickens blood serum. E3S Web of Conferences, vol. 224, p. 04023. https://doi.org/10.1051/e3sconf/202022404023

Postnikova, O. N., Shevkoplyas, L. A., Kuevda, T. A. 2021. Influence of Satureja montana esential oil on the biofilms of opportunistic microorganisns isolated from patients with COVID-19. Problems in medical mycology, vol. 23, no. 2, p. 130. Available at https://mycology.szgmu.ru/images/files/2021/2_2021__Журнал_со_сборником_тезисов.pdf.

Rahimian, F., Eisvand, H. R. 2016. Effects of savory essential oil on germination parameters of Fusarium infected seeds of wheat (Triticum aestivum L.). Iranian Journal of Plant Physiology, vol. 6, no. 3, p. 1745-1750.

Saiyudthong, S., Pongmayteegul, S., Marsden, C. A., Phansuwan-Pujito, P. 2015. Anxiety-like behaviour and c-fos expression in rats that inhaled vetiver essential oil. Natural Product Reserch, vol. 29, no. 22, p. 2141-2144. https://doi.org/10.1080/14786419.2014.992342

Salman, M. T., Ajayi, P. O., Alagbonsi, A. I., Olatunji, L. A. 2017. Artesunate-Induced Hemolysis and Hypoglycemia in Rats: Gender Implication and Role of Antioxidant Enzymes. Journal of Applied Hematology, vol. 8, no. 1, p. 23-32. https://doi.org/10.4103/joah.joah_37_16

Takahashi, M., Yamanaka, A., Asanuma, Ch., Asano, H., Satou, T., Koike, K. 2014. Anxiolytic-like Effect of Inhalation of Essential Oil from Lavandula officinalis: Investigation of Changes in 5-HT Turnover and Involvement of Olfactory Stimulation. Natural Product Communications, vol. 9, no. 7, p. 1023-1026. https://doi.org/10.1177/1934578X1400900735

Vakili, A., Sharifat, S., Akhavan, M. M., Bandegi, A. R. 2014. Effect of lavender oil (Lauandula angustifolia) on cerebral edema and its possible mechanisms in an experimental model of stroke. Brain Research, vol. 1548, p. 56-62. https://doi.org/10.1016/j.brainres.2013.12.019

Widyastuti, N., Anjani, G., Almira, V. G., Putri, S. E., Pratiwi, A. R. 2020. Effects of the administration of brewed Robusta coffee leaves on total antioxidant status in rats with high-fat, high-fructose diet-induced metabolic syndrome. Potravinarstvo Slovak Journal of Food Sciences, vol. 14, no. 1, p. 258-263. https://doi.org/10.5219/1350

Yi, L.-T., Li, J., Geng, D., Liu, B.-B., Fu, Y., Tu, J.-Q., Liu, Y., Weng, L.-J. 2013. Essential oil of Perilla frutescens-induced change in hippocampal expression of brain-derived neurotrophic factor in chronic unpredictable mild stress in mice. Journal of Ethnopharmacology, vol. 147, no. 1, p. 245-53. https://doi.org/10.1016/j.jep.2013.03.015

Yuldashev, A. Yu., Yuldasheva, S. Z., Rakhmatova, M. Kh., Nishanova A. A., Tarinova, M. V. 2014. Morphologic characteristics of fundal part of stomach’s mucosa formation of rats at the postnatal ontogenesis. World of Medicine and Biology, vol. 4, no. 47-2, p. 214-219. Available at https://womab.com.ua/en/smb-2014-04-2/478.

Published

2021-09-17

How to Cite

Pashtetsky, V., Ostapchuk, P., Usmanova, E., Zyablitskaya, E., Makalish, T., Danilova, I., Kuevda, T., Zubochenko, D., Uppe, V., Pashtetskaia, A., Pikhtereva, A., Abalduev, V., Delov, V., & Posobilova, A. (2021). Satureja montana L. essential oil various dosages effect on the main rats’ biological features. Potravinarstvo Slovak Journal of Food Sciences, 15, 799–809. https://doi.org/10.5219/1643