The changes in biochemical parameters due to wine consumption depending on gender

Authors

  • Martina Gažarová Slovak University of Agriculture, Faculty of Agrobiology and Food Resources, Department of Human Nutrition, Tr. A. Hlinku 2, 949 76 Nitra
  • Zuzana Chlebová Slovak University of Agriculture, Faculty of Agrobiology and Food Resources, Department of Human Nutrition, Tr. A. Hlinku 2, 949 76 Nitra
  • Lenka Predná Slovak University of Agriculture, Faculty of Agrobiology and Food Resources, Department of Human Nutrition, Tr. A. Hlinku 2, 949 76 Nitra
  • Peter Chlebo Slovak University of Agriculture, Faculty of Agrobiology and Food Resources, Department of Human Nutrition, Tr. A. Hlinku 2, 949 76 Nitra
  • Marta Habánová Slovak University of Agriculture, Faculty of Agrobiology and Food Resources, Department of Human Nutrition, Tr. A. Hlinku 2, 949 76 Nitra

DOI:

https://doi.org/10.5219/634

Keywords:

red wine, alcohol, health, gender

Abstract

The aim of this study was to investigate the effect of red wine consumption on the lipid profile and glucose in the group of male (13 men aged 34 - 64 years) and the group of female (11 women aged 28 - 57 years). Research consisted of moderate red wine consumption for 6 weeks. The dose of alcohol ranged from 200 to 300 mL per day of red wine Lemberger (Winery Masaryk, Slovakia). The blood samples were obtained after overnight fasting and were collected at baseline and after three days, three weeks and six weeks of wine consumption. Differences between male and female subjects were reflected in the results of different biochemical parameters in the dynamics of wine consumption. We found out that while in females the total cholesterol level did not change significantly and had a predominantly downward trend, for male subjects we observed at the beginning the slight increase of the levels, which, however, after 6 weeks of consumption significantly decreased from an initial value of 5.75 ±1.32 mmol.L-1 to 5.35 ±1.25 mmol.L-1 (<0.05). The blood concentration of triglycerides in the dynamics of the experiment did not change significantly in either one gender, although small differences were observed, because while the female subjects had triglyceride development over consumption upward trend in male subjects it was vice versa. LDL-cholesterol changed significantly only in the group of female. Level of this lipid parameter decreased significantly during the six weeks of consumption of Lemberger from an initial value 3.37 ±0.68 mmol.L-1 to the lowest 2.99 ±0.61 mmol.L-1, which was recorded in the third week of consumption (<0.0001), but statistically significant differences versus baseline we monitored after three days and six weeks of consumption (<0.01). In the group of male, we did not observe such significant changes, but it should be noted, that the men had changes in LDL-cholesterol downward direction and all the values were in the range of benchmarks. In the group of female, HDL-cholesterol increased to 2.05 ±0.6 mmol.L-1 after six weeks of consumption from baseline of 1.7 ±0.69 mmol.L-1, and the difference was statistically significant (<0.05), in the group of male, its level changed first significantly after three days of consumption of steep increase (1.46 ±0.61 mmol.L-1<0.05), and for the next six weeks, it was the significantly increase (1.59 ±0.5 mmol.L-1<0.01). The glucose concentration did not change significantly in the dynamics of wine consumption among men and women, and all the values were between the limits of the standard.

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References

Anagnostis, P., Stevenson, J. C., Crook, D., Johnston, D. G., Godsland, I. F. 2015. Effects of menopause, gender and age on lipids and high-density lipoprotein cholesterol subfractions. Maturitas, 2015, vol. 81, no. 1, p. 62-68. https://doi.org/10.1016/j.maturitas.2015.02.262 PMid:25804951

Baliunas, D. O., Taylor, B. J., Irving, H., Roerecke, M., Patra, J., Mohapatra, S., Rehm, J. 2009. Alcohol as a risk factor for type 2 diabetes: a systematic review andmeta-analysis. Diabetes Care, vol. 32, no. 11, p. 2123-2132. https://doi.org/10.2337/dc09-0227 PMid:19875607

Basu, H., Pernecky, S., Sengupta, A., Liepa, G. U. 2006. Coronary Heart Disease: How Do the Benefits of -3 Fatty Acids Compare with Those of Aspirin, Alcohol/Red Wine, and Statin Drugs? Journal of American Oil Chemists´ Society, vol. 83, no. 12, p. 985-997. https://doi.org/10.1007/s11746-006-5153-4

Bellavia, A., Bottai, M., Wolk, A., Orsini, N. 2014. Alcohol consumption and mortality: a dose-response analysis in terms of time. Annals of Epidemiology, vol. 24, no. 4, p. 291-296. https://doi.org/10.1016/j.annepidem.2013.12.012 PMid:24486142

Brien, S. E., Ronksley, P. E., Turner, B. J., Mukamal, K. J., Ghali, W. A. 2011. Effect of alcohol consumption on biological markers associated with risk of coronary heart disease: systematic review and meta-analysis of interventional studies. BMJ, vol. 342, p. 1-15. https://doi.org/10.1136/bmj.d636 PMid:21343206

Carbonneau, M. A., Leger, C. L., Descomps, B., Michel, F., Monnier, L. 1998. Improvement in the antioxidant status of plasma and low-density lipoprotein in subjects receiving a red wine phenolics mixture. Journal of the American Oil Chemists´ Society, vol. 75, no. 2, p. 235-240.

Cesena, F. H. Y., Coimbra, S. R., Andrade, A. C. M., da Luz, P. L. 2011. The relationship between body mass index and the variation in plasma levels of triglycerides after short-term red wine consumption. Journal of Clinical Lipidology, vol. 5, no. 4, 4-8. https://doi.org/10.1016/j.jacl.2011.04.007 PMid:21784375

Chiva-Blanch, G., Urpi-Sarda, M., Ros, E., Valderas-Martinez, P., Casas, R., Arranz, S., Guillén, M., Lamuela-Raventós, R. M., Llorach, R., Andres-Lacueva, C., Estruch, R. 2013. Effects of red wine polyphenols and alcohol on glucose metabolism and the lipid profile: A randomized clinical trial. Clinical Nutrition, vol. 32, no. 2, p. 200-206. https://doi.org/10.1016/j.clnu.2012.08.022 PMid:22999066

Costanzo, S., Di Castelnuovo, A., Donati, M. B., Iacoviello, L., de Gaetano, G. 2011. Wine, beeror spirit drinking in relation to fatal and non-fatal cardiovascular events: a meta-analysis. European Journal of Epidemiology, vol. 26, no. 11, p. 833-850. https://doi.org/10.1007/s10654-011-9631-0 PMid:22076059

Cullmann, M., Hilding, A., Ostenson, C. G. 2012. Alcohol consumption andrisk of pre-diabetes and type 2 diabetes development in a Swedish population. Diabetic Medicine, vol. 29, no. 4, p. 441-452. https://doi.org/10.1111/j.1464-5491.2011.03450.x PMid:21916972

Devaraj, S., Vega-Lopéz, S., Kaul, N., Schönlau, F., Rohdewald, P., Jialal, I. 2002. Supplementation with a pine bark extract rich in polyphenols increases plasma antioxidant capacity and alters the plasma lipoprotein profile. Lipids, vol. 37, no. 10, p. 931-934. https://doi.org/10.1007/s11745-006-0982-3 PMid:12530550

ESC Pocket Guidelines. 2016. Committee for Practice Guidelines to improve the quality of clinical practice and patient care in Europe [online] s.a. [cit.2016-01-09-8] Available at: www.escardio.org/guidelines.

Estruch, R. 2000. Wine and cardiovascular diseases. Food Research International, vol. 33, no. 3, p. 219-226. https://doi.org/10.1016/S0963-9969(00)00037-5

Fuller, T. D. 2011. Moderate alcohol consumption and the risk of mortality. Demography, vol. 48, no. 3, p. 1105-1125. https://doi.org/10.1007/s13524-011-0035-2 PMid:21594734

Gaag, M. S., Tol, A., Scheek, L. M., James, R. W., Urgert, R., Schaafsma, G., Hendriks, H. F. J. 1999. Daily moderate alcohol consumption increases serum paraoxonase activity; a diet-controlled, randomised intervention study in middle-aged men. Atherosclerosis, vol. 147, no. 2, p. 405-410. https://doi.org/10.1016/S0021-9150(99)00243-9

Gažarová, M., Chlebo, P., Turianica, I., Slezák, F., Rostoka, L. 2008. Analysis of selected wine types focused on their antioxidant capacity and activity. Visnik Stomatologii, vol. 64, no. 4, p. 45-46.

Gorinstein, S., Caspi, A., Zemser, M., Trakhtenberg, S. 2000. Comparative contents of some phenolics in beer, red and white wines. Nutrition Research, vol. 20, no. 1, p. 131-139. https://doi.org/10.1016/S0271-5317(99)00145-1

Grønbaek, M., Becker, U., Johansen, D., Gottschau, A., Schnohr, P., Hein, H. O., Jensen, G., Sørensen, T. I. 2000. Type of alcohol consumed and mortality from all causes, coronary heart disease, and cancer. Annals of Internal Medicine, vol. 133, no. 6, p. 411-419. https://doi.org/10.7326/0003-4819-133-6-200009190-00008 PMid:10975958

Heianza, Y., Arase, Y., Saito, K., Tsuji, H., Fujihara, K., Hsieh, S. D., Kodama, S., Shimano, H., Yamada, N., Hara, S., Sone, H. 2013. Role of alcohol drinking pattern in type 2 diabetes in Japanese men: the Toranomon Hospital Health Management Center study11 (TOPICS 11). American Journal of Clinical Nutrition, vol. 97, no. 3, p. 561-568. https://doi.org/10.3945/ajcn.112.043364 PMid:23343972

Joosten, M. M., Beulens, J. W. J., Kersten, S., Hendriks, H. F. J. 2008. Moderate alcohol consumption increases insulin sensitivity and ADIPOQ expression in postmenopausal women: a randomised, crossover trial. Diabetologia, vol. 51, no. 8, p. 1375-1381. https://doi.org/10.1007/s00125-008-1031-y PMid:18504547

Joosten, M. M., Grobbee, D. E., van der A, D. L., Verschuren, W. M., Hendriks, H. F., Beulens, J. W. 2010. Combined effect of alcohol consumption and lifestyle behaviors on risk of type 2 diabetes. American Journal of Clinical Nutrition, vol. 91, p. 1777-1783. https://doi.org/10.3945/ajcn.2010.29170 PMid:20410096

Kannel, W., Hjortland, M., McNamara, P. 1976. Menopause and risk of cardiovascular disease: the Framingham study. Annals of Internal Medicine, vol. 85, no. 4, p. 447-452. https://doi.org/10.7326/0003-4819-85-4-447 PMid:970770

Kanner, J., Gorelik, S., Roman, S., Kohen, R. 2012. Protection by polyphenols of post-prandial human plasma and low-density lipoprotein modification: the stomachas a bioreactor. Journal of Agricultural and Food Chemistry, vol. 60, no. 63, p. 8790-8796. https://doi.org/10.1021/jf300193g PMid:22530973

Karatzi, K., Karatzis, E., Papamichael, C., Lekakis, J., Zampelas, A. 2009. Effects of red wine onendothelial function: postprandial studies vs clinical trials. Nutrition, Metabolism and Cardiovascular Diseases, vol. 19, no. 10, p. 744-750. https://doi.org/10.1016/j.numecd.2009.04.006 PMid:19570663

Klatsky, A.L., Friedman, G. D., Armstrong, M. A., Kipp, H. 2003. Wine, liquor, beer, and mortality. American Journal of Epidemiology, vol. 158, no. 6, p. 585-595. https://doi.org/10.1093/aje/kwg184 PMid:12965884

Koloverou, E., Panagiotakos, D. B., Pitsavos, C., Chrysohoou, C., Georgousopoulou, E. N., Metaxa, V., Stefanadis, C., ATTICA Study group. 2014. Effects of alcohol consumption and the metabolic syndrome on 10-year incidence of diabetes: The ATTICA study. Diabetes and Metabolism, vol. 41, no. 2, p. 152-159. https://doi.org/10.1016/j.diabet.2014.06.003 PMid:25190450

Koppes, L. L., Dekker, J. M., Hendriks, H. F., Bouter, L. M., Heine, R. J. 2005. Moderate alcohol consumption lowers the risk of type 2 diabetes: a meta-analysis of prospective observational studies. Diabetes Care, vol. 28, no. 3, p. 719-725. https://doi.org/10.2337/diacare.28.3.719 PMid:15735217

Leighton, F., San Martin, A., Castillo, O., Pollak, F., Perez, D. D., Strobel, P., et al. 2000. Red wine, white wine and diet, intervention study. Effect on cardiovascular risk factors. Proc XXV Congrès Mondial de la Vigne et du Vin, Parìs, pp. 63-70.

Leighton, F., Urquiaga, I. 2007. Changes in Cardiovascular Risk Factors Associated with WineConsumption in Intervention Studies in Humans. Annals of Epidemiology, vol. 17, p. 32-36. https://doi.org/10.1016/j.annepidem.2007.01.007

Lorková, M., Kopčeková, J., Gažarová, M., Habánová, M., Chlebo, P., Magula, D., Mrázová, J. 2015. Dietary Patterns And Lifestyle Of PatientsAfter Myocardial Infarction. Potravinarstvo, vol. 9, no. 1, p. 315-323. https://doi.org/10.5219/490

Marques-Vidal, P., Cambou, J. P., Nicaud, V., Luc, G., Evans, A., Arveiler, D., Bingham, A., Cambien, F. 1995. Cardiovascular risk factors and alcohol consumption in France and northern Ireland. Atherosclerosis, vol. 115, no. 5, p. 225-232. https://doi.org/10.1016/0021-9150(94)05517-M

Matthews, K. A., Crawford, S. L., Chae, C. U., Everson-Rose, S. A., Sowers, M. F., Sternfeld, B., Sutton-Tyrrell, K. 2009. Are changes in cardiovascular disease risk factors in midlife women due to chronological aging or to the menopausal transition? Journal of the American College of Cardiology, vol. 5, no. 25, p. 2366-2373. https://doi.org/10.1016/j.jacc.2009.10.009 PMid:20082925

Micallef, M., Lexis, L., Lewandowski, P. 2007. Red wine consumption increases antioxidant status and decreases oxidative stress in the circulation of both young and old humans. Nutrition Journal, vol. 27, no. 6, p. 113-119. https://doi.org/10.1186/1475-2891-6-27

Mosinger, B. 1994. Polyphenolics but not alcohol in beer and wine protect serum low-density lipoprotein against atherogenic modification. Cor Vasa, vol. 4, p. 171-174.

Mukamal, K. J., Jensen, M. K., Gronbaek, M., Stampfer M. J., Manson, J. E., Pischon, T., Rimm, E. B.. 2005. Drinking frequency, mediating biomarkers,and risk of myocardial infarction in women and men. Circulation, vol. 112, no. 10, p. 1406-1413. https://doi.org/10.1161/CIRCULATIONAHA.105.537704 PMid:16129796

Paganga, G., Miller, N., Rice-Evans, C. A. 1999. The polyphenolic content of fruit and vegetables and their antioxidant activities. What does a serving constitute? Free Radical Research, vol. 30, no. 2, p. 153-162. https://doi.org/10.1080/10715769900300161 PMid:10193583

Park, H., Kim, K. 2012. Association of alcohol consumption with lipidprofile in hypertensive men. Alcohol and Alcoholism, vol. 47, no. 3, p. 282-287. https://doi.org/10.1093/alcalc/ags019

PMid:22371847

Rasouli, B., Ahlbom, A., Andersson, T., Grill, V., Midthjell, K., Olsson, L., Carlsson, S. 2013. Alcohol consumption is associated with reduced risk of type 2 diabetesand autoimmune diabetes in adults: results from the Nord-Trondelag healthstudy. Diabetic Medicine, vol. 30, no. 1, p. 56-64. https://doi.org/10.1111/j.1464-5491.2012.03713.x PMid:22612671

Renaud, S. C., Guéguen, R., Conard, P., Lanzmann-Petithory, D., Orgogozo, J. M., Henry, O. 2004. Moderate wine drinkers have lower hypertension-related mortality: a prospective cohort study in French men. American Journal of Clinical Nutrition, vol. 80, no. 3, p. 621-625. PMid:15321801

Renaud, S., de Lorgeril, M. 1992. Wine, alcohol, platelets, and the French paradox for coronary heart disease. Lancet, vol. 339, no. 8808, p. 1523-1526. https://doi.org/10.1016/0140-6736(92)91277-F

Rostron, B. 2012. Alcohol consumption and mortality risks in the USA. Alcohol and Alcoholism, vol. 4, no. 3, p. 334-339. https://doi.org/10.1093/alcalc/agr171 PMid:22278318

Sabaka, P., Mistríková, L., Wawruch, M., Baláž, D., Oravec, S., Dukát, A. 2012. HDL-cholesterol - relevance in clinical practice. Súčasná Klinická Prax, vol. 1, p. 31-35.

Sato, K. K., Hayashi, T., Harita, N., Koh, H., Maeda, I., Endo. G., Nakamura, Y., Kambe, H., Kiyotaki, C. 2012. Relationship between drinking patterns and the risk of type 2diabetes: the Kansai Healthcare Study. Journal of Epidemiology and Community Health, vol. 66, p. 507-511. https://doi.org/10.1136/jech.2010.109777 PMid:21131305

Serafini, M., Maiani, G., Ferro-Luzzi, A. F. 1998. Alcohol free red wine enhances plasma antioxidant capacity in humans. Journal of Nutrition, 1998, vol. 128, no. 6, p. 1003-1007. PMid:9614160

Shai, I., Rimm, E. B., Schulze, M. B., Rifai, N., Stampfer, M. J., Hu, F. B. 2004. Moderate alcohol intake and markers of inflammation and endothelial dysfunction among diabetic men. Diabetologia, vol. 47, no. 10, p. 1760-1767. https://doi.org/10.1007/s00125-004-1526-0 PMid:15502925

Shi, L., Shu, X. O., Li, H., Cai, H., Liu Q., Zheng W. Xiang, Y. B., Villegas, R. 2013. Physical activity,smoking, and alcohol consumption in association with incidenceof type 2 diabetes among middle-aged and elderly Chinese men. PLoS One, vol. 8, no. 11, p. e77919. https://doi.org/10.1371/journal.pone.0077919 PMid:24223743

Sierksma, A., Vermunt, S. H. F., Lankhuizen, I. M., van der Gaag, M. S. Scheek, L. M., Grobbee, D. E., van Tol, A., Hendriks, H. F. J. 2004. Effect of Moderate Alcohol Consumption on Parameters of Reverse Cholesterol Transport in Postmenopausal Women. Alcoholism: Clinical and Experimental Research, vol. 28, no. 4, p. https://doi.org/10.1097/01.ALC.0000122763.30770.F5

Tsang, C., Higgins, S., Duthie, G. G., Duthie, S. J., Howie, M., Mullen, W., Lean, E. J., Crozier, A. 2005. The influence of moderate red wine consumption on antioxidant status and indices of oxidative stress associated with CHD in healthy volunteers. British Journal of Nutrition, vol. 93, p. 233-240. https://doi.org/10.1079/BJN20041311 PMid:15788107

Xin, P., Pan, Y., Zhu, W., Huang, S., Wel, M., Chen, C. 2010. Favorable effects of resferatrol on sympathetic neural remodeling in rats following myocardial infarction. European Journal of Pharmacology, vol.649, no. 1, p. 293-300. https://doi.org/10.1016/j.ejphar.2010.09.036 PMid:20869962

Xin, X., He, J., Frontini, M. G., Ogden, L. G., Motsamai, O. I., Whelton, P. K. 2001. Effects of alcohol reduction on blood pressure: a meta-analysisof randomized controlled trials. Hypertension, vol. 38, no. 5, p. 1112-1117. https://doi.org/10.1161/hy1101.093424 PMid:11711507

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Published

2016-09-29

How to Cite

Gažarová, M. ., Chlebová, Z. ., Predná, L. ., Chlebo, P. ., & Habánová, M. . (2016). The changes in biochemical parameters due to wine consumption depending on gender. Potravinarstvo Slovak Journal of Food Sciences, 10(1), 437–443. https://doi.org/10.5219/634

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